Further experiences with methylated thiobarbiturates.

FIG. 1 Formulae of the drug under study. Limited supplies of two further methylated thiobarbiturates, described by Peel et al. (1959), known as B.82 and B.133 have become available. The formulae of these are shown in figure 1 and it can be seen that B.82 is the methylated form of buthalitone. B.133 is not related chemically to any thiobarbiturate in clinical use, being sodium N-methyl 5-ethyl 5'-isobutyl thiobarbiturate. This paper reports on a clinical trial of these two compounds in which their effects are compared with those of thiopentone and buthalitone.